Cuvette for Cadaveric Eye on Artificial Anterior Chamber

Authors: Giancarlo Paternoster, Patrick Lopath, Dr. Roy Chuck

Project Completed: February 2025

This custom-designed cuvette enables precise measurement of drug influx and efflux in the eye, providing critical data for ophthalmic research. Integrated into a cadaveric eye system, it works with an artificial anterior chamber mounted upside down to mimic physiological conditions while allowing continuous monitoring of drug movement through corneal and intraocular tissues. The controlled environment ensures highly reproducible measurements, helping to characterize the diffusion properties of various ophthalmic drugs.

By capturing real-time drug concentration changes, this system offers valuable insights into the kinetics of drug absorption, retention, and elimination. The data obtained is essential for optimizing therapeutic formulations, refining drug delivery techniques, and improving treatment strategies for ocular diseases. This innovative approach enhances the understanding of corneal permeability and intraocular drug dynamics, supporting advancements in ophthalmic pharmacology and clinical care.